Evidence map›Paper›PMID 41170834›Full record

ArticleJournal of the American College of Surgeons2026

Intraoperative Hemodynamic Management During Esophagectomy and Implications for Postoperative Care.

Jonathan E Williams, Samantha L Savitch, Faelan Jacobson-Davies, Tyler M Bauer, Ryan C Jacobs, Patrick L Johnson, Kiran H Lagisetty, Andrew C Chang, Douglas Colquhoun, David D Odell

Abstract read
In one paragraph

Article in Journal of the American College of Surgeons, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jonathan E WilliamsFrom the Department of Surgery, Michigan Medicine, Ann Arbor, MI (Williams, Savitch, Bauer, Johnson, Lagisetty, Chang, Odell).
Samantha L SavitchFrom the Department of Surgery, Michigan Medicine, Ann Arbor, MI (Williams, Savitch, Bauer, Johnson, Lagisetty, Chang, Odell).
Faelan Jacobson-DaviesCenter for Healthcare Outcomes and Policy, University of Michigan, Ann Arbor, MI (Williams, Savitch, Jacobson-Davies, Bauer, Johnson, Odell).
Tyler M BauerFrom the Department of Surgery, Michigan Medicine, Ann Arbor, MI (Williams, Savitch, Bauer, Johnson, Lagisetty, Chang, Odell).
Ryan C JacobsDepartment of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL (Jacobs).
Patrick L JohnsonFrom the Department of Surgery, Michigan Medicine, Ann Arbor, MI (Williams, Savitch, Bauer, Johnson, Lagisetty, Chang, Odell).
Kiran H LagisettyFrom the Department of Surgery, Michigan Medicine, Ann Arbor, MI (Williams, Savitch, Bauer, Johnson, Lagisetty, Chang, Odell).
Andrew C ChangFrom the Department of Surgery, Michigan Medicine, Ann Arbor, MI (Williams, Savitch, Bauer, Johnson, Lagisetty, Chang, Odell).
Douglas ColquhounDepartment of Anesthesiology, Michigan Medicine, Ann Arbor, MI (Colquhoun).
David D OdellFrom the Department of Surgery, Michigan Medicine, Ann Arbor, MI (Williams, Savitch, Bauer, Johnson, Lagisetty, Chang, Odell).

Funding

Interdisciplinary Research Training Center in Cancer Care DeliveryT32CA236621 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Lauren P Wallner · 2020 to 2026
$2.8M
Obesity Surgery Scientist Training ProgramT32DK108740 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Justin Brigham Dimick, RANDY J SEELEY · 2016 to 2026
$2.2M
Data Driven Approaches to Improving Risk Prediction of Pulmonary Complications After Major Inpatient SurgeryK08HL159327 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI COLQUHOUN, DOUGLAS ALASTAIR · 2021 to 2025
$811k
NCI NIH HHS T32 CA236621NHLBI NIH HHS K08 HL159327NIDDK NIH HHS T32 DK108740
6 · The paper itself

Abstract

backgroundEsophagectomy remains a high-morbidity operation despite advances in perioperative care. The relationship between intraoperative hemodynamic management and postoperative complications remains undefined. This study explores real-time hemodynamic management patterns and postoperative complications after esophagectomy. STUDY

designUsing a paired anesthesia and surgical registry, patients undergoing elective esophagectomy at a single high-volume institution between 2015 and 2023 were analyzed. Patients were categorized by fluid-restrictive or fluid-liberal intraoperative volume strategies and vasopressor-low or vasopressor-high strategies based on cumulative dose required during the case. Additionally, anesthesiologists were characterized similarly according to their relative average fluid and vasopressor administrations. Adjusted rates of select and composite postoperative complications were compared by fluid and vasopressor strategies using multivariable logistic regression.

resultsOf 639 patients, 296 (46.3%) received a fluid-restrictive strategy and 343 (53.7%) received a fluid-liberal strategy. Three hundred nineteen patients (49.9%) occupied the vasopressor-low category, whereas 320 (50.1%) were in the vasopressor-high category. Across the cohort, the unadjusted leak rate was 23.2%, pneumonia 10.6%, and atrial fibrillation 32.3%. There were no significant differences in adjusted rates of complications between fluid and vasopressor groups. Patients managed by fluid-liberal anesthesiologists had higher adjusted rates of atrial fibrillation (19.6% vs 27.2%, odds ratio 1.60 [1.00 to 2.57], p = 0.049).

conclusionsHemodynamic management during esophagectomy is variable. Intraoperative volume balance or vasopressor administration may not be associated with differential complication rates; however, further analysis is warranted. This may inform postoperative management by identifying at-risk patients for complications, thereby individualizing treatment decision-making.

Indexed as

EsophagectomyFluid TherapyHemodynamicsIntraoperative CarePostoperative CarePostoperative ComplicationsAgedEsophageal NeoplasmsFemaleHumansMaleMiddle AgedRegistriesRetrospective StudiesVasoconstrictor AgentsVasoconstrictor Agents

Identifiers

PMID41170834
PMCPMC12616549

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.