ArticleAnalytical chemistry2025
Effects of Charged Surface on Electrochemical Sensitivity to Protein Dimerization.
Article in Analytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Protein dimerization is a crucial biological process in which proteins interact into homo- or heterodimers to form a functional assembly. Understanding and modulating the molecular mechanisms of protein dimerization and their function represent the cutting edge of research and provide multiple entries for biomedical applications. Label-free methods sensitive to homodimer formation are still required. Electrochemical methods are sensitive to small structural changes due to the presence of a surface and polarization to high negative/positive potentials, where partial denaturation/unfolding can appear. Since the dimeric structure is usually more flexible, the electric field effects induce more salient structural changes close to the electrode surface, accompanied by higher chronopotentiometric/voltammetric responses. Serum albumin and anterior gradient receptor-2 were studied as model homodimeric proteins.
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