ArticleAnnals of medicine2025
Impact of perioperative platelet counts and IL-6 on wound healing outcomes after thoracoscopic lung cancer surgery.
Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundWound healing complications remain significant concerns following thoracoscopic surgery for lung cancer. Perioperative hematological indicators, particularly platelet counts and inflammatory markers, are crucial factors influencing wound healing. Given these gaps, we retrospectively investigated the effect of these indicators on postoperative wound healing outcomes in lung cancer surgery.
methodsWe conducted a retrospective analysis of 200 patients who underwent thoracoscopic surgery for lung cancer. We assessed platelet counts, IL-6, IL-10, TNF-α, and other hematological markers. Patients were stratified by platelet counts into high and low groups. Correlations between these hematological parameters and clinical outcomes, including intraoperative blood loss, hospitalization duration, and wound healing status, were analysed.
resultsHigher perioperative platelet counts were significantly associated with reduced intraoperative bleeding (
conclusionPerioperative platelet counts and inflammatory markers, particularly IL-6, significantly influence wound healing in lung cancer surgery. Higher platelet counts were associated with better early postoperative outcomes, while elevated IL-6 levels predict adverse wound healing events. Preoperative IL-6 screening could flag patients who benefit from intensified anti-inflammatory care; multicentre trials with longer follow-up are warranted.
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