ArticleHealth science reports2025
Causal Associations Between 4907 Circulating Proteins and Hyperlipidemia: A Two-Sample Mendelian Randomization Study Based on European Ancestry.
Article in Health science reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Causal Associations Between 4907 Circulating Proteins and Hyperlipidemia: A Two-Sample Mendelian Randomization Study Based on European Ancestry.Health science reports · 2025Article
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Authors and funding
2 authors.
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Abstract
Background and Objective: This study employed Mendelian randomization (MR) to investigate the causal relationships between 4907 circulating proteins and hyperlipidemia, with the aim of identifying potential drug targets. Methods: Instrumental variables were derived from genome-wide association study (GWAS) data on 4907 circulating proteins. Causal associations between exposures and outcome were assessed using MR analysis. Sensitivity analyses were conducted to identify circulating proteins most strongly associated with hyperlipidemia. Finally, enrichment analysis was performed on positively associated proteins to identify disease-related pathways. Results: MR analysis identified 70 disease-associated proteins, including 47 positively correlated and 23 negatively correlated with hyperlipidemia. Enrichment analysis revealed significant pathways related to hyperlipidemia, such as the adipocytokine signaling pathway and axon guidance. Conclusion: This study identified several circulating proteins significantly associated with hyperlipidemia. The large sample size minimized confounding factors, providing valuable insights for clinical treatment strategies.
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