ArticleJournal of asthma and allergy2025
Nonlinear Relationship Between Body Mass Index Z-Scores and Lung Function Parameters in Asthmatic Children: A Cross-Sectional Study.
Article in Journal of asthma and allergy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- The moderating effect of body mass index on the association between lung function and physical fitness among adolescents.Frontiers in public health · 2026Article
- Impact of atmospheric NOFrontiers in public health · 2026Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: To assess the relationship between body mass index (BMI) and BMI z-scores with lung function parameters in children with asthma, aiming to provide scientific evidence for individualized treatment and management strategies. Methods: We enrolled 328 children with asthma during acute exacerbation. The BMI and BMI z-scores were analyzed in relation to lung function parameters, including maximum vital capacity (VCmax), forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), peak expiratory flow (PEF), maximal mid-expiratory flow rate (MMEF), and instantaneous flows at 25%, 50%, and 75% of maximal expiratory flow (MEF25, MEF50, MEF75). Both linear regression and piecewise regression models were used to identify linear associations and potential threshold effects. Results: BMI showed significant positive linear correlations with VCmax, FVC, FEV1, MEF50, MEF75, and MMEF, while BMI z-scores demonstrated positive linear associations with VCmax, FVC, FEV1, MEF25, MEF50, and MMEF. After adjusting for age, sex, immunoglobulin E (IgE), eosinophil count (EOS), fractional exhaled nitric oxide (FeNO), and asthma severity, both BMI and BMI z-scores remained positively associated with VCmax, FVC, and FEV1. Piecewise regression analysis revealed significant threshold effects in the relationships between BMI z-scores and VCmax, FVC, FEV1, PEF, MEF25, MEF50, MEF75, and MMEF. Below a z-score of ~2.3-3.9, BMI z-score was positively associated with pulmonary function. Above this threshold, the association reversed; for instance, FEV1 decreased by 9.7% (β = -9.69, 95% CI: -18.93 to -0.46) and PEF decreased by 12.2% (β = -12.17, 95% CI: -21.12 to -3.22) for every unit increase in BMI z-score beyond 3.945. Conclusion: A nonlinear relationship exists between BMI z-scores and lung function parameters in children with asthma. Weight-guided interventions may enhance lung function and asthma control.
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