ArticleFrontiers in pharmacology2025
Efficacy and safety of live combined
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Live combined Methods: Randomized controlled trials (RCTs) assessing the efficacy or safety of LCBE in patients with constipation, published before September 2025, were comprehensively searched for in Wan Fang, China National Knowledge Infrastructure, China Science and Technology Journal Database, Web of Science, Cochrane Library, and PubMed. Efficacy and safety outcomes were extracted. Results: A total of 32 studies were included, containing 1,565 patients receiving LCBE and control treatment (experimental group) and 1,490 patients receiving control treatment alone (control group). The experimental group showed a higher total effective rate [odds ratio (OR) (95% confidence interval (CI)) = 5.789 (4.598-7.288); Conclusion: LCBE demonstrates a favorable efficacy and good tolerability in patients with constipation. This meta-analysis provides supportive evidence for its clinical application in the management of constipation.
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Registered trials
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