ArticleFrontiers in nutrition2025
Epigenetic landscape reveals
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: We investigated epigenetic mechanisms underlying muscle development in black Tibetan sheep fed different dietary ratios of non-fiber carbohydrate to neutral detergent fiber (NFC/NDF), integrating phenotypic analyses (growth performance, meat quality, muscle histomorphology) with multi-omics approaches (ATAC-seq, H3K27ac CUT&Tag, RNA-seq). Methods: The subjects were 2-month-old weaned male Tibetan sheep with an initial body weight of 10.45 ± 0.96 kg. Using a completely randomized study design, 90 sheep were randomly assigned to three treatment groups with 30 sheep per group. Each treatment group consisted of 5 pens with 6 sheep per pen. The dietary NFC/NDF ratios of these three treatment groups were 0.71 (Group L), 1.16 (Group M) and 1.82 (Group H). Results: An NFC/NDF ratio of 1.82 yielded optimal growth performance with increased live weight, carcass weight, and dressing percentage. This ratio significantly improved meat tenderness, water-holding capacity, and pH values while reducing hardness and chewiness, accompanied by compact muscle fiber architecture. Epigenomic analyses revealed epigenetic signals predominantly localized within distal intergenic regions (10-100 kb). Enhancers showed dynamic responsiveness to dietary NFC/NDF changes, with Discussion: These findings elucidate how dietary NFC/NDF ratios optimize muscle development through enhancer activation, providing insights for precision nutrition strategies in livestock production.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.