ReviewFrontiers in cellular and infection microbiology2025
Crosstalk between neutrophil extracellular traps and gut microbiota in ulcerative colitis: traditional Chinese medicine strategies.
Review in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Identification of IL1RN, MUC1, and SERPINA1 as key NET-related biomarkers in ulcerative colitis-associated intestinal fibrosis via bioinformatics and experimental validation.BMC gastroenterology · 2026Article
- Multi-Dimensional Mechanisms and Druggability Optimization Strategies of Active Ingredients from Traditional Chinese Medicine in the Treatment of Ulcerative Colitis.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Therapeutic Potential of Kinkeliba (Molecules (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ulcerative colitis (UC), a chronic and complex inflammatory bowel disorder, presents ongoing therapeutic challenges. Although multi-tiered anti-inflammatory strategies represent significant advances, issues like treatment resistance and adverse effects persist. Consequently, identifying more effective therapeutic targets and potentially curative strategies remains imperative. Emerging evidence underscores neutrophils, particularly through neutrophil extracellular trap (NET) formation, as pivotal contributors to UC pathogenesis. In affected individuals, excessive NET accumulation exacerbates intestinal inflammation, compromises the epithelial barrier, activates coagulation pathways, promotes resistance to biologic therapies, and may even facilitate malignant transformation. Critically, a bidirectional interplay exists between NETs and the gut microbiota (GM) in this disease. Recent research indicates that certain traditional Chinese medicine (TCM) herbal extracts and formulas hold promise for modulating aberrant NET generation and GM composition. This review examines the roles of NETs and GM in UC pathogenesis and synthesizes evidence on potential TCM-based interventions targeting these pathways, offering novel perspectives for future therapeutic development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.