ArticleInternational journal of endocrinology2025
Increased Serum Lipopolysaccharide Levels are Related to a Higher Prevalent Risk of Subclinical Hypothyroidism.
Article in International journal of endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: This study aimed to assess the relationship between serum lipopolysaccharide levels and subclinical hypothyroidism in a southern Chinese adult population. Methods: This cross-sectional community-based study included 2577 participants. Fasting venous samples were taken to examine lipopolysaccharide, thyroid hormone, thyroglobulin antibody, and thyroid peroxidase antibody levels. The population was divided into quartiles according to serum lipopolysaccharide levels. A multivariable-adjusted logistic regression model was applied to test the association between lipopolysaccharide and subclinical hypothyroidism. Results: Participants with increased serum levels of lipopolysaccharide had a higher prevalence of Hashimoto's thyroiditis (Q1: 10.4%, Q2: 14.3%, Q3: 17.8%, and Q4: 29.5%; Conclusions: Increased serum lipopolysaccharide levels were related to an increased prevalence of subclinical hypothyroidism in the southern Chinese adult population.
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