Evidence map›Paper›PMID 41170172›Full record

ArticleFrontiers in human neuroscience2025

Loudness dependence of auditory evoked potentials reflects trait anxiety and harm avoidance in healthy adults: an exploratory study.

Kohei Fujita, Nobuyuki Takeuchi, Shunsuke Sugiyama, Koji Inui, Yuki Fujita, Ami Yamaba, Taeko Kamiya, Takahiro Ushida, Kousuke Kanemoto, Jun Miyata and 1 more

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Article in Frontiers in human neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Kohei FujitaNeuropsychiatric Department, Aichi Medical University, Nagakute, Japan.
Nobuyuki TakeuchiBijutsukanmae Mental Clinic, Okazaki, Japan.
Shunsuke SugiyamaDepartment of Psychiatry and Psychotherapy, Gifu University, Gifu, Japan.
Koji InuiDepartment of Integrative Physiology, National Institute for Physiological Sciences, Okazaki, Japan.
Yuki FujitaCentral Clinical Laboratory, Aichi Medical University Hospital, Nagakute, Japan.
Ami YamabaCentral Clinical Laboratory, Aichi Medical University Hospital, Nagakute, Japan.
Taeko KamiyaCentral Clinical Laboratory, Aichi Medical University Hospital, Nagakute, Japan.
Takahiro UshidaMultidisciplinary Pain Center, Aichi Medical University, Nagakute, Japan.
Kousuke KanemotoNeuropsychiatric Department, Aichi Medical University, Nagakute, Japan.
Jun MiyataNeuropsychiatric Department, Aichi Medical University, Nagakute, Japan.
Makoto NishiharaNeuropsychiatric Department, Aichi Medical University, Nagakute, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Loudness dependence of auditory-evoked potentials (LDAEP), a neurophysiological measure that reflects central serotonergic activity, is also influenced by the noradrenaline and dopamine systems. While it has been used in investigations of various psychiatric disorders, the fundamental characteristics in healthy individuals remain largely unknown. The present exploratory study examined 60 healthy adults to determine the associations of LDAEP with psychological traits assessed using the Temperament and Character Inventory (TCI) and State-Trait Anxiety Inventory (STAI). The participants completed TCI and STAI questionnaires before undergoing electrophysiological recordings. LDAEP was measured based on the peak-to-peak amplitude slopes of P50/N100 and N100/P200 across five sound intensity levels. Using Spearman's correlation analysis, moderate negative correlations of LDAEP slopes with harm avoidance (HA) and trait anxiety (STAI-T) scores were noted. Additionally, sex-adjusted analysis showed novelty seeking to be positively associated with LDAEP. These findings suggest an association of LDAEP with individual differences in harm avoidance, trait anxiety, and novelty seeking in healthy adults. This supports the potential use of LDAEP as a non-invasive biomarker to predict treatment response in major depressive disorder, as well as in anxiety-related conditions.

Indexed as

anxietyharm avoidanceLoudness Dependence of Auditory Evoked Potentials (LDAEP)novelty seekingserotoninState-Trait Anxiety Inventory (STAI)Temperament and Character Inventory (TCI)

Identifiers

PMID41170172
PMCPMC12568648

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.