ArticleChina CDC weekly2025
Prospective Study on Clinical Performance of Host DNA Methylation Assay for Triage in Women Who Are HPV-Positive - 4 Provinces, China, 2018-2021.
Article in China CDC weekly, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Diagnostic Accuracy of DNA Methylation Markers for Detecting Cervical Precancer and Cervical Cancer: A Systematic Review and Meta-analysis.Archives of academic emergency medicine · 2026Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
What is already known about this topic?: Persistent infection with high-risk human papillomavirus (hrHPV) is recognized as the primary cause of cervical cancer and its precancerous lesions. However, most HPV infections are transient and naturally clear. Currently effective triage tools for distinguishing between transient HPV infections and clinically relevant hrHPV-induced diseases are lacking, leading to excessive referrals and overtreatment. What is added by this report?: This is the first large-scale, prospective, multicenter study to evaluate the triage performance of host DNA six-methylation marker assay ( What are the implications for public health practice?: The large number of women with HPV infections in China each year has led to excessive cytological screenings and colposcopy referrals. A feasible triage tool for women who are hrHPV-positive significantly reduces unnecessary medical resource utilization and offers substantial health and economic benefits.
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