ArticleInfection and drug resistance2025
Efficacy and Safety of Low-Dose Trimethoprim-Sulfamethoxazole (TMP-SMZ) for the Prevention of
Article in Infection and drug resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Prophylaxis Regimens forJournal of fungi (Basel, Switzerland) · 2026Review
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To evaluate the noninferiority and safety of low-dose trimethoprim-sulfamethoxazole (TMP-SMZ, 200/40 mg qd) with respect to conventional-dose TMP-SMZ in preventing Methods: This retrospective cohort study included patients who received PJP-preventing therapy at the First Affiliated Hospital of Zhejiang University School of Medicine from April 2021 to December 2023. The patients were divided into low-dose group (TMP-SMZ 200/40 mg qd, n=57) and conventional-dose group (400/80 mg qd, n=65). The primary endpoint was the 90-day incidence of PJP, and the secondary endpoints included all-cause mortality and adverse drug events (assessed on the basis of the Common Terminology Criteria for Adverse Events (CTCAE) 5.0 and Kidney Disease: Improving Global Outcomes (KDIGO) criteria). Results: No patients in either group developed PJP within 90 days (risk difference (RD) = 0, 95% confidence interval (CI): -0.05 to 0.05). There was no statistically significant difference in the incidence of adverse reactions (ARs), such as hematologic toxicity (granulocytopenia: 5.26% vs 1.54%, p=0.339), liver injury, and kidney injury, between the low-dose group and the conventional-dose group. The median survival time was 193 days in the low-dose group vs 130 days in the conventional-dose group (p=0.312). Conclusion: In non-HIV, non-transplant, immunosuppressed patients, the efficacy of low-dose TMP-SMZ (200/40 mg/d) in the prevention of PJP was not inferior to that of conventional-dose TMP-SMZ, and the safety profiles of the two doses were equivalent.
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