Evidence map›Paper›PMID 41170086›Full record

ArticleBioinformation2025

Systemic versus topical administration of antioxidants in radiation-induced oral mucositis.

Saikiran Bahadur, Diksha Koushal, Eesha, Rajeeth Shetty, Alpana Kanwar, Rahul Kumar Tomar, Sitesh Kumar Samal

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioinformation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Saikiran BahadurDepartments of Prosthodontics, Springfield Dental, Springfield, Massachussets, United State of America.
Diksha KoushalDepartment of Oral Medicine and Radiology, Jaipur Dental College, Jaipur, Rajasthan, India.
EeshaDepartment of Oral Pathology & Microbiology, Regional Dental College (RDC), Guwahati, India.
Rajeeth ShettyDepartment of Oral and Maxillofacial Surgery, Srinivas Institute of Dental Sciences, Mukka, Mangalore, Karnataka, India.
Alpana KanwarDepartment of Oral and Maxillofacial Pathology & Microbiology, Maharaja Ganga Singh Dental College and Research Centre, Sri Ganga Nagar, Rajasthan, India.
Rahul Kumar TomarDapartment of Oral Pathology and Microbiology, DJ College of Dental Sciences and Research, Modinagar, Ghaziabad, Uttar Pradesh, India.
Sitesh Kumar SamalIntern, Kalinga Institute of Dental Science, Kalinga Institute of Industrial Technology (KIIT) Deemed to be University, Patia, Bhubaneswar, Odisha, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral mucositis (OM) is a debilitating complication of radiotherapy in head and neck cancer patients. This study was done to compare the efficacy of systemic versus topical antioxidant therapy in preventing and managing radiation-induced oral mucositis. Total 150 head and neck cancer patients undergoing radiotherapy were divided into systemic antioxidants and topical antioxidants groups. Further subdivide into three subgroups based on the antioxidant agent used. Clinical parameters were assessed using the WHO oral mucositis scale. Both systemic and topical antioxidants reduced the severity of OM; however, topical antioxidants, especially curcumin gel, showed superior efficacy.

Indexed as

antioxidantscurcumin gelOral mucositisradiation therapyVitamin E

Identifiers

PMID41170086
PMCPMC12569905

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.