Evidence map›Paper›PMID 41170027›Full record

ArticleBioinformation2025

Research landscape of precision medicine in cardiology.

Shrinidhi Sivasubramaniam, Keerthika Muniasamy, Elakkiya L, Sanjit Pradeep, Rohan D, Yogesh S, Sree Nithish Kanna Baskaran, Kaarthik Akash Srikanth

Abstract read
In one paragraph

Article in Bioinformation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shrinidhi SivasubramaniamInstitute of Internal Medicine, Madras Medical College, Chennai, India.
Keerthika MuniasamyDepartment of Surgery, Madras Medical College, Chennai, India.
Elakkiya LInstitute of Internal Medicine, Madras Medical College, Chennai, India.
Sanjit PradeepDepartment of Internal Medicine, Sri Ramachandra Institute of Higher Education and Research, Chennai, India.
Rohan DInstitute of Internal Medicine, Madras Medical College, Chennai, India.
Yogesh SInstitute of Internal Medicine, Madras Medical College and RGGGH, Chennai and MHPE SCHOLAR, Sri Balaji Vidyapeeth, Pondicherry, India.
Sree Nithish Kanna BaskaranDuty Medical Officer, ICU, SRM Global Hospitals, Kattankulathur, Tamil Nadu, India.
Kaarthik Akash SrikanthDepartment of Internal Medicine, Thanjavur Medical College, Thanjavur, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Precision medicine in cardiology integrates genomic, proteomic, and phenotypic data to tailor prevention, diagnosis, and treatment strategies for individual patients. Recent advances have identified genetic variants associated with arrhythmias, cardiomyopathies, and coronary artery disease, enabling risk stratification and targeted therapies. High-throughput "omics" technologies and machine-learning algorithms have facilitated the discovery of novel biomarkers and have refined phenotypic subgroups within heterogeneous cardiac disorders. Pharmacogenomic profiling has demonstrated potential to optimize drug selection and dosing, reducing adverse events and improving therapeutic efficacy. Despite these breakthroughs, challenges such as data integration, clinical implementation barriers, and ethical considerations remain. Ongoing efforts in large-scale consortia, real-world data registries, and adaptive clinical trial designs are expanding the evidence base. This review synthesizes the current research landscape, highlights emerging technologies, and discusses future directions for personalized cardiovascular care.

Indexed as

biomarkerscardiovascular phenotypinggenomic medicinemachine learningpersonalized therapypharmacogenomicsPrecision cardiology

Identifiers

PMID41170027
PMCPMC12569861

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.