ArticleHeart rhythm O22025
The efficiency and safety of zero-exchange workflows in pulsed field ablation: Comprehensive insights from the DISRUPT-AF registry.
Article in Heart rhythm O2, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06335082 (A Registry Based Collaborative to Measure Efficiency, Effectiveness, and Safety of Farapulse Pulsed Field Ablation Technology for Atrial Fibrillation), which is not on this map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Registry Based Collaborative to Measure Efficiency, Effectiveness, and Safety of Farapulse Pulsed Field Ablation Technology for Atrial Fibrillation
Who cites it
2 citing papers in PubMed.
- Evolution of Radiofrequency Transseptal Puncture Devices.Medical devices (Auckland, N.Z.) · 2026Review
- Assessing the Feasibility of Radiofrequency Wire-Based Transseptal Puncture in Fluoroscopy-Only Pulsed Field Ablation Workflows.Journal of cardiovascular electrophysiology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Pulsed field ablation (PFA) has revolutionized catheter ablation procedures in terms of safety, efficiency, and efficacy. Streamlined zero-exchange workflows with therapy sheath integrated transseptal puncture (TSP) devices may offer further improvements. However, the impact of device exchanges on real-world PFA procedures remains unknown. Objective: We aimed to describe and quantify procedural characteristics associated with different PFA workflows. Methods: The DISRUPT-AF registry (NCT06335082) is an observational, prospective study assessing clinical experience with the pentaspline PFA system in the United States. Procedures are performed as per standard-of-care, where specific workflows and left atrial (LA) access devices were not mandated. Results: A total of 873 cases (mean age, 68.0 ± 11.4 years; 38.6% women) with 62 unique operators across 20 centers were assessed. Of these, 10.1%, 63.1%, and 26.8% reported "0"-, "1-2"-, and "3+"-exchanges, respectively. Regardless of atrial fibrillation subtype, zero-exchange workflows were associated with significantly shorter and more consistent TSP times (0:5.7 ± 4.2 min; 1-2:15.3 ± 7.3 min; 3+:19.2 ± 9.3 min; Conclusion: The adoption of zero-exchange workflows enabled by therapy sheath-integrated TSP devices results in significant improvements in procedural efficiency and predictability without compromising patient safety or acute outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.