ArticleHeart rhythm O22025
Impact of left atrial anatomy on pulmonary vein isolation with cryoballoon ablation: Insights from the randomized controlled COMPARE CRYO study.
Article in Heart rhythm O2, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Left atrial anatomy and atrial arrhythmia recurrence after pulsed-field ablation.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026Article
- The safety and effectiveness of a modified guidewire pigtailing technique in transesophageal echocardiography-guided percutaneous closure of secundum atrial septal defects.BMC cardiovascular disorders · 2026Article
Corrections and comments
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Authors and funding
22 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Cryoballoon ablation is an established therapy for pulmonary vein (PV) isolation (PVI). Objective: This study aimed to explore whether specific left atrial anatomical features are associated with both first-pass PVI success and long-term outcomes after cryoballoon ablation using 2 different cryoablation systems. Methods: Left atrial reconstructions of patients with paroxysmal atrial fibrillation were analyzed. PVI was performed using either the Medtronic (Minneapolis, MN) Arctic Front Advance or the Boston Scientific (Marlborough, MA) POLARx cryoablation catheter. Anatomical features were assessed to predict first-pass PVI success after a single application and long-term outcomes on the basis of implantable cardiac monitor recordings. Results: A total of 191 patients were enrolled (mean age 63.0 ± 9.8 years; 58 (30%) women). First-pass PVI was achieved in 69% of all procedures. Female sex was significantly associated with reduced first-pass isolation success, limited to the right superior PV (odds ratio [OR] 0.50; 95% confidence interval [CI] 0.26-0.97; Conclusion: The absence of an orthogonal orientation of the left-sided PVs was significantly associated with lower first-pass isolation rates and a higher risk of recurrence. These findings highlight the importance of preprocedural anatomical assessment to identify potential challenges and tailor ablation strategies.
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