ArticleJournal of traditional and complementary medicine2025
Cardiotoxic effects of Bisphenol-A in male Wistar rats are attenuated by
Article in Journal of traditional and complementary medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: The heart, due to its high energetic metabolic and reactive oxygen production rate, is a target for oxidative stress-related injuries. Therefore, environmental toxicants such as Bisphenol-A (BPA), that exert pathologies through oxidative and nitrite stress-related mechanism may target the heart for their deleterious effects. This study was therefore designed to investigate the effect of two naturally occurring antioxidants, Methods: Fifty-six animals were divided into 7equal groups and treated orally for 28days as follows; groups I(control) and II(vehicle) received distilled water(1.5 mL/kg) and corn oil(1.5 mL/kg) respectively. Animals in groups III-V received BPA (50 mg/kg) only, BPA + GK (200 mg/kg), BPA + kolaviron (200 m/kg) respectively, while animals in groups VI-VII received GK and kolaviron only, respectively. Thereafter, blood pressure and electrocardiogram were evaluated in each group and under anesthesia, cardiac samples were excised and analyzed for oxidative stress status, inflammatory markers and histology, respectively. Results: BPA-only exposed rats exhibited cardiac dysfunction manifested by elevated systolic blood pressure and cardiac inflammatory markers, reduced cardiac antioxidants and distorted structural aberrations. Treatment of BPA exposed animals with either GK or kolaviron mitigated the development of these dysfunctions in varying degrees, while treatment of either GK or kolaviron alone in the absence of BPA exposure showed significant antioxidant and anti-inflammatory potentials. Conclusion: These results suggests that
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.