Evidence map›Paper›PMID 41169944›Full record

ArticleJournal of traditional and complementary medicine2025

Repurposing Suan-Zao-Ren-Tang as anticancer agents in apoptotic sensitization against non-small cell lung cancer cell lines through amplification of spindle assembly checkpoint activation.

Yu-Chi Hsiao, Yi-Hua Sheng, Tse-Yu Chen, Wohn-Jenn Leu, Jui-Ling Hsu, Lih-Ching Hsu, Lie-Chwen Lin, Jih-Hwa Guh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of traditional and complementary medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yu-Chi HsiaoSchool of Pharmacy, National Taiwan University, No. 33, Linsen S. Rd., Taipei, 100, Taiwan.
Yi-Hua ShengSchool of Pharmacy, National Taiwan University, No. 33, Linsen S. Rd., Taipei, 100, Taiwan.
Tse-Yu ChenSchool of Pharmacy, National Taiwan University, No. 33, Linsen S. Rd., Taipei, 100, Taiwan.
Wohn-Jenn LeuSchool of Pharmacy, National Taiwan University, No. 33, Linsen S. Rd., Taipei, 100, Taiwan.
Jui-Ling HsuSchool of Pharmacy, National Taiwan University, No. 33, Linsen S. Rd., Taipei, 100, Taiwan.
Lih-Ching HsuSchool of Pharmacy, National Taiwan University, No. 33, Linsen S. Rd., Taipei, 100, Taiwan.
Lie-Chwen LinNational Research Institute of Chinese Medicine, Ministry of Health and Welfare, No. 155-1, Section 2, Linong St, Taipei 11221, Taiwan.
Jih-Hwa GuhSchool of Pharmacy, National Taiwan University, No. 33, Linsen S. Rd., Taipei, 100, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Treatment of non-small cell lung cancer (NSCLC) is a high unmet medical need. We repurposed Suan-Zao-Ren-Tang (SZRT), a widely used traditional Chinese medicine in alleviating insomnia, to sensitize vinorelbine-induced anti-NSCLC effect and have unveiled the underlying mechanism. B7E2, the partial purified extract from SZRT, was used through bioactivity-guided fractionation based on anti-proliferative activity in NSCLC cell lines A549 and NCI-H460. Three batches of B7E2 and their individual components were prepared for the examination of components and bioactivity and mechanistic study. B7E2 alone had no cytotoxic effect but its combination with vinorelbine displayed a synergistic activity in killing NSCLC cells. Apoptotic sensitization was verified by a remarkable increase of caspase activation and phosphorylation of Bcl-2 and Bcl-xL. Combination treatment prolonged mitotic arrest and induced a substantial activation of spindle assembly checkpoint (SAC) characterized by BUBR1 phosphorylation at Ser670 and Thr680, and cyclin B1 upregulation. Combination treatment enhanced the interaction between mitotic checkpoint complex (MCC) components, including BUBR1, MAD2, BUB3 and CDC20. Further analysis revealed that SZRT components, including senkyunolide-A,

Indexed as

Combination treatmentNon-small cell lung cancerSpindle assembly checkpointSuan-Zao-Ren-TangVinorelbine

Identifiers

PMID41169944
PMCPMC12570107

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.