Evidence map›Paper›PMID 41169877›Full record

ArticleFrontiers in cardiovascular medicine2025

Increasing arterial compliance by laser modification of fibro-calcific plaques.

S Rajebahadur, N Velluva Rayaroth, J B King, Yu M Alexandrovskaya, G Guagliumi, A Glatz, J E Johnson, F Miranda Romero, D Vela, V M Vinokur and 2 more

Abstract read
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In one paragraph

Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

S RajebahadurBeckman Laser Institute and Medical Clinic, University of California Irvine, Irvine, CA, United States.
N Velluva RayarothBeckman Laser Institute and Medical Clinic, University of California Irvine, Irvine, CA, United States.
J B KingBeckman Laser Institute and Medical Clinic, University of California Irvine, Irvine, CA, United States.
Yu M AlexandrovskayaTerra Quantum AG, St. Gallen, Switzerland.
G GuagliumiInterventional Cardiology, IRCCS Galeazzi Sant'Ambrogio Hospital, Milan, Italy.
A GlatzDepartment of Physics, Northern Illinois University, DeKalb, IL, United States.
J E JohnsonBeckman Laser Institute and Medical Clinic, University of California Irvine, Irvine, CA, United States.
F Miranda RomeroBeckman Laser Institute and Medical Clinic, University of California Irvine, Irvine, CA, United States.
D VelaThe Texas Heart Institute at Baylor College of Medicine, Houston, TX, United States.
V M VinokurTerra Quantum AG, St. Gallen, Switzerland.
T E MilnerBeckman Laser Institute and Medical Clinic, University of California Irvine, Irvine, CA, United States.
E N SobolTerra Quantum AG, St. Gallen, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Calcium is a constituent of numerous types of atherosclerotic plaques. While various vessel modification devices have been introduced, plaque heterogeneity presents a challenge to direct therapy to specific components within the arterial wall. Aims: We introduce a novel approach for non-destructive modification of arterial fibrocalcific plaques with controlled spatial-temporal diode-laser irradiation. The laser thermomechanical approach enables the controlled formation of microstructural defects, stress relaxation, microcracking, and plaque molding. Primary objectives of this exploratory study include: (1) Determine an optimal laser dosimetry in fibro-calcific plaques in Methods: Diode laser radiation with a wavelength of 1,470 nm is delivered to Results: A candidate window for laser dosimetry is determined both theoretically and experimentally in the range of 150-300 W/cm Conclusion: This proof-of-concept study demonstrated that modulated diode laser irradiation can modify the mechanical and structural characteristics of fibrocalcific arteries and increase vessel compliance. Additional studies are required in arteries with different levels of calcification and plaque distribution to optimize laser dosimetry for targeted vessel modifications.

Indexed as

arterial compliancecalcified plaquescardio-vascular diseaselasernon-destructive modification

Identifiers

PMID41169877
PMCPMC12568616

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.