Evidence map›Paper›PMID 41169805›Full record

ArticleWellcome open research2025

Coxsackievirus A24 variant whole genome sequencing from clinical samples using a three overlapping amplicons strategy.

John Mwita Morobe, Samuel Odoyo, Arnold W Lambisia, Edidah Moraa, Charlotte J Houldcroft, Edward C Holmes, George Githinji, Charles N Agoti

Abstract read
In one paragraph

Article in Wellcome open research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

John Mwita MorobeKenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme (KWTRP), Kilifi, Kilifi County, Kenya.ORCID https://orcid.org/0000-0003-2398-6717
Samuel OdoyoKenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme (KWTRP), Kilifi, Kilifi County, Kenya.ORCID https://orcid.org/0000-0002-5882-2416
Arnold W LambisiaKenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme (KWTRP), Kilifi, Kilifi County, Kenya.ORCID https://orcid.org/0000-0001-5312-0960
Edidah MoraaKenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme (KWTRP), Kilifi, Kilifi County, Kenya.
Charlotte J HouldcroftDepartment of Genetics, University of Cambridge, Cambridge, England, UK.
Edward C HolmesSchool of Medical Sciences, The University of Sydney, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0001-9596-3552
George GithinjiKenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme (KWTRP), Kilifi, Kilifi County, Kenya.ORCID https://orcid.org/0000-0001-9640-7371
Charles N AgotiKenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme (KWTRP), Kilifi, Kilifi County, Kenya.ORCID https://orcid.org/0000-0002-2160-567X

Funding

Wellcome Trust
6 · The paper itself

Abstract

In January 2024, the Kenya Ministry of Health issued an outbreak alert following a surge in acute hemorrhagic conjunctivitis (AHC) cases along the Kenyan coast. Our investigations identified coxsackievirus A24 variant (CV-A24v) as the causative agent. In this study, we developed a novel whole genome sequencing assay for CV-A24v, and used it to recover three near complete genomes from the 2024 AHC outbreak in Kenya. This method will support future studies on CV-A24v genomic epidemiology and evolution across Kenya and beyond.

Indexed as

Acute Hemorrhagic Conjunctivitis KenyaCoxsackievirus A24 variantNext generation sequencing

Identifiers

PMID41169805
PMCPMC12569506

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.