Evidence map›Paper›PMID 41169793›Full record

ArticleMaterials today. Bio2025

Zaotang-inspired pull-folding approach to fabricate oriented multifunctional scaffolds for bone repair.

Zongying Zhang, Huitao Qi, Fei Xuan, Dan Wang, Qian Kong, Zhijuan Ai, Dongming Xing, Zhongmin Geng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zongying ZhangCancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266071, China.
Huitao QiTrauma Orthopedics, People's Hospital Affiliated to Shandong First Medical University, Jinan, 271100, Shandong, China.
Fei XuanOncology Department, People's Hospital Affiliated to Shandong First Medical University, Jinan, 271100, Shandong, China.
Dan WangCancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266071, China.
Qian KongCancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266071, China.
Zhijuan AiCancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266071, China.
Dongming XingCancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266071, China.
Zhongmin GengCancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266071, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone defects caused by trauma, tumors, or infections impose significant clinical challenges due to donor scarcity and complications in traditional grafting. Current scaffold fabrication techniques like electrospinning and 3D printing face limitations in mechanical strength, process complexity, and production costs. Herein, we developed a cost-effective, solvent-free fabrication method inspired by traditional Chinese "Zaotang" candy-pulling techniques. By blending polycaprolactone (PCL) and collagen under controlled heating, a malleable composite was formed, which then mimicked Zaotang's honeycomb-forming process, repetitive pulling and folding of the semi-solid mixture induced structural orientation and porosity without solvents or specialized equipment. Subsequent in situ mineralization with strontium-apatite (SrAP) further augments bioactivity, leveraging Sr

Indexed as

Bone regenerationPull-folding approachStrontium-apatiteVascular remodeling

Identifiers

PMID41169793
PMCPMC12569817

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.