Evidence map›Paper›PMID 41169780›Full record

ArticleJournal of conservative dentistry and endodontics2025

Evaluating immunohistochemical and genetic expression of green-mediated nano-enhanced glass ionomer cement: An animal model study.

Soorya Ganesh, Jessy Paulraj, Subhabrata Maiti, Karthik Ganesh Mohanraj, Selvaraj Jayaraman

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In one paragraph

Article in Journal of conservative dentistry and endodontics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

5 authors.

Soorya GaneshDepartment of Pedodontics and Preventive Dentistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India.
Jessy PaulrajDepartment of Pedodontics and Preventive Dentistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India.
Subhabrata MaitiDepartment of Prosthodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India.
Karthik Ganesh MohanrajDepartment of Anatomy, Biomedical Research Unit and Lab Animal Centre, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India.
Selvaraj JayaramanDepartment of Biochemistry, Centre of Molecular Medicine and Diagnostics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim: This study aimed to compare the immunohistochemical (IHC) and genetic expression in tissues exposed to green-mediated nano-enhanced glass ionomer cement (GIC) and conventional GIC using an animal model. Materials and Methods: This study investigated the IHC and genetic expression of green-mediated nano-enhanced GIC reinforced with chitosan, titanium, zirconia, and hydroxyapatite nanoparticles. These nanoparticles were integrated into the GIC powder, and nine disc-shaped specimens (5 mm diameter and 2 mm thickness) were fabricated. The specimens were implanted subcutaneously into the dorsal region of 18 Wistar albino rats. Group I received conventional GIC ( Results: Both the GIC groups showed increased IL-6 and TNF-α on day 3 compared to sham, indicating inflammation. On day 3, IL-6 was higher in conventional GIC (1.26 ± 0.020) and nano-modified GIC (1.23 ± 0.011) compared to sham (1.0 ± 0.001), but by day 30, the levels were similar across all the groups. TNF-α was elevated in both the GIC groups on day 3, with conventional GIC (1.15 ± 0.141) and nano-modified GIC (1.05 ± 0.109), and equal across the groups by day 30. Conclusion: Green-mediated nano-enhanced GIC caused less inflammation and upregulated healing genes compared to conventional GIC, suggesting better integration and improved clinical outcomes. Long-term studies are needed to confirm these benefits.

Indexed as

Dental materialsmodified glass ionomer cementnanoparticlesrestorative dentistry

Identifiers

PMID41169780
PMCPMC12571465

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