ArticleJournal of conservative dentistry and endodontics2025
Biocompatibility of novel premixed putty calcium silicate-based cement on human dental pulp stem cells: An
Article in Journal of conservative dentistry and endodontics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Cytotoxicity and Bioactivity of Five Hydraulic Silicate Cements in Human Dental Pulp Cells at Different Setting Stages.International dental journal · 2026Article
- Dental Glass Ionomer Cement for Root Perforation Management: Physicochemical Characteristics and In Vitro Cell Response.Dentistry journal · 2026Article
- Macrophage-Marker Response and Exploratory Hepatorenal Safety of a Tricalcium Silicate-Biogenic Calcium Carbonate (International journal of dentistry · 2026Article
- Novel acemannan-integrated bioceramic for enhancing human dental pulp stem cell viability and transforming growth factor beta-1 release in pulp regeneration.Journal of conservative dentistry and endodontics · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Vital pulp therapy aims to preserve pulp vitality by promoting reparative dentin formation through bioactive materials that support human dental pulp stem cells (hDPSCs) proliferation. Objectives: This study compared the biocompatibility of premixed putty calcium-silicate-based cement (C-SbC) with mineral trioxide aggregate (MTA) on hDPSCs in terms of viability, proliferation, and mineralization potential. Materials and Methods: hDPSCs were divided and cultured in six different groups: MTA, premixed putty C-SbC (Bio-C Repair) at 1:1, 1:2, and 1:4 dilutions, and DMEM as control. Viability and proliferation were assessed using MTT and trypan blue staining after 24 h. Mineralization potential was evaluated qualitatively using Alizarin Red staining after 21 days. Statistical analysis was performed using the one-way analysis of variance and Bonferroni post hoc test ( Results: All the groups showed cell viability with no significant differences in proliferation potential at 24 h. However, cell counts indicated a significant increase in hDPSCs with all concentrations of premixed putty C-SbC compared to MTA ( Conclusion: Premixed putty C-SbC, particularly at a 1:1 concentration, demonstrated superior biocompatibility and mineralization potential compared to MTA, making it a promising material for vital pulp therapy.
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Registered trials
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