ArticleJournal of conservative dentistry and endodontics2025
Impact of collagen cross-linking agents on release of hydroxyproline from radicular dentin in endodontically treated mandibular premolars with bio-ceramic sealers: An
Article in Journal of conservative dentistry and endodontics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Context: Bio ceramic sealers are effective in sealing root canals but their high alkalinity may degrade radicular dentin collagen, compromising tooth strength. Collagen cross-linking agents have the potential to protect and stabilize collagen. Cross-linking agents are used to create chemical bonds between collagen molecules. This process stabilizes the collagen structure, making it more resistant to degradation by enzymes like collagenase. A reduction in the amount of hydroxyproline (HYP) released indicates that the cross-linking agent is effectively protecting the collagen from breakdown. Aims: To evaluate the effect of collagen cross-linking agents on collagen degradation by measuring HYP release. Methodology: Forty mandibular premolars were decoronated, instrumented to ProTaper F2, and irrigated with 5.25% NaOCl and 17% ethylenediaminetetraacetic acid. Samples were divided into four groups: Group 1 (6.5% proanthocyanidin [PA]), Group 2 (cashew nut shell liquid [CNSL]), Group 3 (chlorhexidine), and Group 4 (saline). Canals were obturated with gutta-percha and bio-ceramic sealer, then stored in artificial saliva. HYP release was measured on days 7, 14, and 21 using spectrophotometry. Statistical Analysis Used: The amount of HYP released was analyzed using one-way analysis of variance, Kruskal-Wallis test, and Tukey honestly significant difference test. Results: Groups 1 and 2 exhibited significantly lower HYP release than Groups 3 and 4, indicating reduced collagen degradation. Conclusions: Collagen cross-linking agents, especially PA and CNSL, reduce collagen breakdown and may improve dentin durability following bio-ceramic sealer application.
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