Evidence map›Paper›PMID 41169742›Full record

ArticleFrontiers in neuroscience2025

Brainstem neurochemical profiles after hospitalisation for COVID-19: a 7T MR spectroscopy study.

Carina Graf, Betty Raman, Anne Manktelow, Doris A Chatfield, William T Clarke, Catarina Rua, Virginia F J Newcombe, Victoria C Lupson, Stephen J Sawcer, Joanne G Outtrim and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Carina GrafWolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.
Betty RamanDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, Oxford University Hospitals NHS Foundation Trust, University of Oxford, Oxford, United Kingdom.
Anne ManktelowDivision of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
Doris A ChatfieldWolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.
William T ClarkeWellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
Catarina RuaWolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.
Virginia F J NewcombeWolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.
Victoria C LupsonWolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.
Stephen J SawcerDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.
Joanne G OuttrimDivision of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
Karen D ErscheDepartment of Psychiatry, University of Cambridge, Cambridge, United Kingdom.
Lin QiuNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.
Martyn EzraNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.
Rory McDonaldNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.
Stuart ClareNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.
Mark Philip CassarDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, Oxford University Hospitals NHS Foundation Trust, University of Oxford, Oxford, United Kingdom.
Stefan NeubauerDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, Oxford University Hospitals NHS Foundation Trust, University of Oxford, Oxford, United Kingdom.
Edward T BullmoreDepartment of Psychiatry, University of Cambridge, Cambridge, United Kingdom.
David K MenonDivision of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
James B RoweDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.
Kyle PattinsonNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.
Christopher T RodgersWolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.
Cambridge NeuroCOVID group
CITIID-NIHR COVID-19 BioResource Collaboration

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Somatic, cognitive and mental health issues have been identified in three-quarters of people 5 months after hospitalisation for severe acute SARS-CoV-2 (COVID-19) infection. The underlying neuroanatomical basis of these symptoms remains unclear, but recent studies suggest a role for altered brainstem physiology. We aimed to test the hypothesis that brainstem neurochemical profiles differ in patients who had been hospitalised for COVID-19 compared to matched controls using 7T magnetic resonance spectroscopy (MRS). Methods: This prospective case-control study recruited 34 individuals who were hospitalised for COVID-19 and 15 healthy controls with no history of COVID-19 infection from two major UK hospitals before vaccines became available. The participants underwent 7T semi-adiabatic localization by adiabatic selective refocusing (sLASER) Results: Spectral quality was high/acceptable in 44/49 participants according to the MRS Consensus criteria. The magnitude of inflammation during patient admission (i.e., CRP Conclusion: We show the feasibility of assessing brainstem neurochemical profiles using 7T

Indexed as

7TbrainstemCOVID-19magnetic resonance spectroscopyneuroinflammation

Identifiers

PMID41169742
PMCPMC12568683

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.