Evidence map›Paper›PMID 41169734›Full record

ArticleRespirology case reports2025

Good's Syndrome Presenting With Weaning Failure From Ventilation and Myasthenia Gravis in a Post-Thymectomy Patient.

Asmita Anilkumar Mehta, Aditya Ashok, Lakshmi Priya Valathara Pradeep, Suchitra Sivadas, George Justin Mothi

Abstract read
In one paragraph

Article in Respirology case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Asmita Anilkumar MehtaDepartment of Respiratory Medicine Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeethem Kochi India.ORCID https://orcid.org/0000-0003-2937-0454
Aditya AshokDepartment of Respiratory Medicine Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeethem Kochi India.
Lakshmi Priya Valathara PradeepDepartment of Respiratory Medicine Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeethem Kochi India.
Suchitra SivadasDepartment of Hematology Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeethem Kochi India.
George Justin MothiMedical Trust Hospital Kochi India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Good's syndrome is a rare adult-onset immunodeficiency associated with thymoma, hypogammaglobulinemia, and cellular immune dysfunction. We report a man in his 50s with a prior thymectomy who presented with recurrent pneumonia, chronic diarrhoea, and failure to wean from non-invasive ventilation. Flow cytometry revealed absent B cells and an inverted CD4/CD8 ratio, confirming Good's syndrome. He also developed myasthenia gravis, which contributed to ventilatory failure but improved with pyridostigmine. The patient responded well to monthly intravenous immunoglobulin therapy and remained clinically stable at follow-up. This case emphasises the importance of suspecting Good's syndrome in patients with thymoma and unexplained infections, as early recognition and timely immunoglobulin replacement are essential for improving outcomes.

Indexed as

immunoglobulin deficiencymyasthenia gravisrecurrent infectionsthymoma

Identifiers

PMID41169734
PMCPMC12569607

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.