ArticleFrontiers in digital health2025
App-based multimodal lifestyle-intervention for essential hypertension (HYPE): a decentralized randomised controlled trial.
Article in Frontiers in digital health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Application of digital health technologies in hypertension self-management: a narrative review.Frontiers in public health · 2026Review
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Authors and funding
6 authors.
Funding
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Abstract
Background: Life-style interventions are effective in lowering blood pressure (BP) and reducing cardiovascular risk, but implementation is poor. We aimed to evaluate the efficacy of an app-based multimodal lifestyle intervention in reducing BP in patients with uncontrolled hypertension. Methods: In a decentralized, single-blinded, randomized-controlled trial, adults with uncontrolled hypertension by home BP measurement were randomized to 12 weeks of app-based multimodal lifestyle intervention or care as usual. The primary outcome was the difference of mean systolic BP after 12 weeks. Secondary outcomes were mean diastolic BP difference, and changes in body weight, health-related quality of life, and food literacy. An intention-to-treat analysis with multiple imputation by chained equations (MICE) was performed. Results: From June 13, 2024, to September 30, 2024, a total of 139 pts. were randomized with a mean baseline BP of 142/88 mmHg, of which 55% were females. After 12 weeks, there was a significantly lower systolic BP in the intervention group (-8.5 mmHg, [95% CI: -11.0 to -5.9], Conclusion: A digital multimodal lifestyle intervention may clinically improve general hypertension care and should be evaluated in larger trials.
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