ReviewFrontiers in molecular biosciences2025
Mechanistic insights into cisplatin-induced ototoxicity: the central role of transient receptor potential channels.
Review in Frontiers in molecular biosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Local application of otoprotective compounds other than sodium thiosulfate to prevent cisplatin-induced hearing loss: a systematic review.Drug delivery · 2026Pooled it
- A Newly Identified Role of the Tectorial Membrane in Aminoglycoside Ototoxicity.bioRxiv : the preprint server for biology · 2026Article
- Review
- Advances in pathogenesis, novel therapeutic strategies and interventions for age-related hearing loss.Frontiers in molecular neuroscience · 2026Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review systematically elucidates the molecular mechanisms underlying cisplatin-induced ototoxicity, with a particular focus on the pivotal role played by TRP channels. First, the article outlines the uptake and efflux pathways of cisplatin within cochlear hair cells, followed by a detailed analysis of the core mechanisms by which cisplatin damages these cells. It emphasizes the structural and functional characteristics of TRP channels and their action mechanisms in cisplatin ototoxicity, elucidating the channels' high selectivity for calcium ions and their central role in driving ototoxicity. Additionally, the review explores the roles of other TRP family members in regulating hair cells. Finally, based on an analysis of the limitations of existing otoprotective strategies, the review proposes future precision prevention and treatment strategies targeting TRP channels. These include novel nanodelivery technologies and multi-pathway combined interventions, providing a new theoretical foundation and translational direction for protecting against cisplatin ototoxicity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.