Evidence map›Paper›PMID 41169595›Full record

ArticleJACS Au2025

Merging Central and Axial Chirality in Cyclic(alkyl)(amino)carbenes: The Keystone for High Enantioselectivities in Ru-Catalyzed Asymmetric Olefin Metathesis.

Meng Liu, Dylan Bouëtard, Jakub Talcik, Jan Lorkowski, Ziyun Zhang, Thomas Vives, Thierry Roisnel, Muriel Serradeil-Albalat, Nicolas Vanthuyne, Luigi Cavallo and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACS Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Meng LiuÉcole Nationale Supérieure de Chimie de Rennes, CNRS, ISCR UMR 6226, Univ Rennes, F-35000 Rennes, France.
Dylan BouëtardÉcole Nationale Supérieure de Chimie de Rennes, CNRS, ISCR UMR 6226, Univ Rennes, F-35000 Rennes, France.
Jakub TalcikÉcole Nationale Supérieure de Chimie de Rennes, CNRS, ISCR UMR 6226, Univ Rennes, F-35000 Rennes, France.
Jan LorkowskiÉcole Nationale Supérieure de Chimie de Rennes, CNRS, ISCR UMR 6226, Univ Rennes, F-35000 Rennes, France.
Ziyun ZhangChemical and Life Sciences and Engineering, Kaust Catalysis Center, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia.
Thomas VivesÉcole Nationale Supérieure de Chimie de Rennes, CNRS, ISCR UMR 6226, Univ Rennes, F-35000 Rennes, France.ORCID https://orcid.org/0000-0001-6533-0703
Thierry RoisnelÉcole Nationale Supérieure de Chimie de Rennes, CNRS, ISCR UMR 6226, Univ Rennes, F-35000 Rennes, France.ORCID https://orcid.org/0000-0002-6088-4472
Muriel Serradeil-AlbalatCNRS, Centrale Med, FSCM, Aix Marseille Univ., Chiropole, 13013 Marseille, France.ORCID https://orcid.org/0000-0002-0215-0999
Nicolas VanthuyneCNRS, Centrale Med, FSCM, Aix Marseille Univ., Chiropole, 13013 Marseille, France.ORCID https://orcid.org/0000-0003-2598-7940
Luigi CavalloChemical and Life Sciences and Engineering, Kaust Catalysis Center, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia.ORCID https://orcid.org/0000-0002-1398-338X
Laura FaliveneDipartimento di Chimica, Università di Salerno, Via Ponte don Melillo, I-84084 Fisciano, Italy.ORCID https://orcid.org/0000-0003-1509-6191
Rodolphe JazzarUCSD-CNRS Joint Research Laboratory (IRL 3555), Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, United States.
Marc MauduitÉcole Nationale Supérieure de Chimie de Rennes, CNRS, ISCR UMR 6226, Univ Rennes, F-35000 Rennes, France.ORCID https://orcid.org/0000-0002-7080-9708

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of 38 chiral ruthenium complexes containing cyclic-(alkyl)-(amino)-carbene (CAAC) ligands with axial C-N chirality have been developed. By merging axial and central chirality, very high enantioselectivity (up to >99% ee) as well as good to high

Indexed as

asymmetric catalysisCAACDFT calculationligand designolefin metathesisruthenium

Identifiers

PMID41169595
PMCPMC12569691

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.