Evidence map›Paper›PMID 41169594›Full record

ArticleJACS Au2025

The Unique Properties and Click Capacity of the Tetrazine Group Enable Tetrazine Allyl Acetate to Serve as a Versatile Bis-Thiol Bioconjugation and Functionalization Agent.

Hang Xu, Mengyang Chang, Yue Dong, Fangchao Bi, Hongmin Li, Wei Wang

Abstract read
In one paragraph

Article in JACS Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hang XuDepartment of Pharmacology and Toxicology, University of Arizona Cancer Center and BIO5 Institute, University of Arizona, Tucson, Arizona 85721, United States.
Mengyang ChangDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona 85721, United States.
Yue DongDepartment of Pharmacology and Toxicology, University of Arizona Cancer Center and BIO5 Institute, University of Arizona, Tucson, Arizona 85721, United States.
Fangchao BiDepartment of Pharmacology and Toxicology, University of Arizona Cancer Center and BIO5 Institute, University of Arizona, Tucson, Arizona 85721, United States.
Hongmin LiDepartment of Pharmacology and Toxicology, University of Arizona Cancer Center and BIO5 Institute, University of Arizona, Tucson, Arizona 85721, United States.ORCID https://orcid.org/0000-0002-8684-5308
Wei WangDepartment of Pharmacology and Toxicology, University of Arizona Cancer Center and BIO5 Institute, University of Arizona, Tucson, Arizona 85721, United States.ORCID https://orcid.org/0000-0001-6043-0860

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The inverse electron demand Diels-Alder (IEDDA) click reaction of tetrazine (Tz) with

Indexed as

bis-thiol bioconjugationIEDDApeptide/protein modificationtetrazine ligationtrans-cyclooctene

Identifiers

PMID41169594
PMCPMC12569695

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.