ArticleJACS Au2025
Annulation of Hydroxyarenes and Derivatives with Bicyclo[1.1.0]butanes by Synergistic Combination of Metal Lewis Acid and Organic Acid.
Article in JACS Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Recent Progress in Coupling Reactions Involving the Novel Substrate of Bicyclo[1.1.0]butane (BCB).Topics in current chemistry (Cham) · 2026Review
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of new approaches to synthesize complex structures from readily available compounds is a topic of significant interest in synthetic chemistry. Herein, we present a straightforward strategy to access structurally intriguing arene-fused bicyclo[2.1.1]-hexanes by Lewis acid-catalyzed annulation of hydroxyarenes and their ether derivatives with bicyclo[1.1.0]-butanes (BCBs). This reaction presumably proceeded through a cascade initiated by a dearomative (3 + 2) cycloaddition followed by rearomatization through alcohol or water elimination. The employment of acidic hexafluoroisopropanol (HFIP) as a solvent proved essential for facilitating this transformation by a synergistic combination with Lewis acid. This methodology could accommodate a broad array of commercially available arene materials including phenols, anisoles, and naphthyl methyl ethers, thus allowing rapid generation of molecular complexity, which expands synthetic access to the chemical space of bridged polycycles.
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