Evidence map›Paper›PMID 41169574›Full record

ArticleJACS Au2025

Unified Chemical Synthesis of Corynanthe-Sarpagine-Ajmaline Type Monoterpene Indole Alkaloids: A Biomimetic Approach.

Ya-Kui Sun, Xiao-Feng Guo, Yu Bu, Jin-Bao Qiao, Yu-Ming Zhao

Abstract read
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In one paragraph

Article in JACS Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ya-Kui SunKey Laboratory of Applied Surface and Colloid Chemistry of MOE & School of Chemistry and Chemical Engineering, Shaanxi Normal University, 620 West Chang'an Ave, Xi'an, 710119, China.
Xiao-Feng GuoKey Laboratory of Applied Surface and Colloid Chemistry of MOE & School of Chemistry and Chemical Engineering, Shaanxi Normal University, 620 West Chang'an Ave, Xi'an, 710119, China.
Yu BuKey Laboratory of Applied Surface and Colloid Chemistry of MOE & School of Chemistry and Chemical Engineering, Shaanxi Normal University, 620 West Chang'an Ave, Xi'an, 710119, China.
Jin-Bao QiaoKey Laboratory of Applied Surface and Colloid Chemistry of MOE & School of Chemistry and Chemical Engineering, Shaanxi Normal University, 620 West Chang'an Ave, Xi'an, 710119, China.
Yu-Ming ZhaoKey Laboratory of Applied Surface and Colloid Chemistry of MOE & School of Chemistry and Chemical Engineering, Shaanxi Normal University, 620 West Chang'an Ave, Xi'an, 710119, China.ORCID https://orcid.org/0000-0003-0337-2558

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The biosynthesis and chemical synthesis of corynanthe-sarpagine-ajmaline type monoterpene indole alkaloids, which share a close structural relationship, have presented key challenges in this field for decades. Herein, we present a biomimetic synthesis strategy inspired by biosynthetic hypotheses, successfully achieving a unified chemical synthesis of various corynanthe-sarpagine-ajmaline type polycyclic alkaloids. The success of this approach is attributed to (1) the rapid construction of chemically synthesized intermediates that closely resemble universally accepted biosynthetic intermediates via a sequence of formal Michael addition and

Indexed as

biomimetic synthesis strategyMannich reactionMichael additionmonoterpene indole alkaloids

Identifiers

PMID41169574
PMCPMC12569679

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.