Evidence map›Paper›PMID 41169553›Full record

ArticleJACS Au2025

Synthesis of

Marina Degač, Lena Reininger, Hanna Schardax, Erik Andris, Lubomír Rulíšek, Ivana Císařová, Uwe Rinner, Timothée Cadart, Martin Kotora

Abstract read
In one paragraph

Article in JACS Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Marina DegačDepartment of Organic Chemistry, Faculty of Science, Charles University, Hlavova 8, 128 00 Praha 2, Czech Republic.
Lena ReiningerDepartment of Organic Chemistry, Faculty of Science, Charles University, Hlavova 8, 128 00 Praha 2, Czech Republic.
Hanna SchardaxDepartment of Organic Chemistry, Faculty of Science, Charles University, Hlavova 8, 128 00 Praha 2, Czech Republic.
Erik AndrisInstitute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i. Flemingovo náměstí 2, 160 00 Praha 6, Czech Republic.ORCID https://orcid.org/0000-0002-9336-0157
Lubomír RulíšekInstitute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i. Flemingovo náměstí 2, 160 00 Praha 6, Czech Republic.ORCID https://orcid.org/0000-0002-7769-7059
Ivana CísařováDepartment of Inorganic Chemistry, Faculty of Science, Charles University, Hlavova 8, 128 00 Praha 2, Czech Republic.ORCID https://orcid.org/0000-0002-9612-9831
Uwe RinnerInstitute of Applied Chemistry, IMC Krems University of Applied Sciences, Piaristengasse 1, 3500 Krems, Austria.
Timothée CadartDepartment of Organic Chemistry, Faculty of Science, Charles University, Hlavova 8, 128 00 Praha 2, Czech Republic.
Martin KotoraDepartment of Organic Chemistry, Faculty of Science, Charles University, Hlavova 8, 128 00 Praha 2, Czech Republic.ORCID https://orcid.org/0000-0003-4491-7091

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Skeletal editing of 5-membered carbocycles to 6-membered heteroaromatic compounds represents an attractive concept that would enable late-stage heteroarene construction. However, the current state of the art does not offer many synthetic strategies on how to achieve such a goal. One of those is based on a reaction of aromatic tertiary alcohols with sodium azide under acidic conditions, i.e., the Schmidt reaction. Herein, we present a hitherto unexplored double Schmidt reaction toward aromatic compounds possessing two pyridine rings. It is the first example of a conversion of 5,8-disubstituted indeno-[2,1-

Indexed as

diazaheliceneenantioselectivityreaction mechanismSchmidt reactionskeletal editing

Identifiers

PMID41169553
PMCPMC12569675

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.