ArticleJACS Au2025
Expanding the Chemical Space of Mechanically Interlocked Peptides (MIPs) via Rational Design and Metabolite Profiling.
Article in JACS Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Tangled Tail of Mechanically Interlocked Peptides.Journal of the American Chemical Society · 2026Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mechanically interlocked peptides (MIPs) possess exceptional biological stability, making them promising scaffolds for therapeutic development. However, despite advances in biological and chemical synthesis, their accessible chemical space remains limited. In particular, practical methodologies and rational design principles for mechanically interlocking and stabilizing conventional linear peptides are still underdeveloped. Here, we present a robust strategy for peptide interlocking and stabilization using active-template Cu-(I)-catalyzed azide-alkyne cycloaddition (AT-CuAAC). Through systematic exploration of amino acid side chains, macrocycle size, peptide length, and reaction conditions, we established design guidelines and constructed a diverse library of interlocked short peptides. This approach was further applied to longer peptide sequence, [Y]
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