Evidence map›Paper›PMID 41169509›Full record

ArticleiScience2025

Intracellular lactate dynamics in

Matthew S Price, Elham Rastegari, Richa Gupta, Katie Vo, Travis I Moore, Kartik Venkatachalam

Abstract read
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Matthew S PriceDepartment of Integrative Biology and Pharmacology, McGovern Medical School at the University of Texas Health Sciences Center (UTHealth), Houston, TX, USA.
Elham RastegariDepartment of Integrative Biology and Pharmacology, McGovern Medical School at the University of Texas Health Sciences Center (UTHealth), Houston, TX, USA.
Richa GuptaDepartment of Integrative Biology and Pharmacology, McGovern Medical School at the University of Texas Health Sciences Center (UTHealth), Houston, TX, USA.
Katie VoDepartment of Integrative Biology and Pharmacology, McGovern Medical School at the University of Texas Health Sciences Center (UTHealth), Houston, TX, USA.
Travis I MooreDepartment of Integrative Biology and Pharmacology, McGovern Medical School at the University of Texas Health Sciences Center (UTHealth), Houston, TX, USA.
Kartik VenkatachalamDepartment of Integrative Biology and Pharmacology, McGovern Medical School at the University of Texas Health Sciences Center (UTHealth), Houston, TX, USA.

Funding

Neuropathology in tauopathies stem from depolarization-induced alterations in the planar distribution of phosphoinositidesRF1AG069076 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI VENKATACHALAM, KARTIK · 2020 to 2020
$1.8M
Alterations in somatodendritic bioenergetics in Drosophila models of tauopathyRF1AG072176 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI VENKATACHALAM, KARTIK · 2021 to 2021
$1.2M
Mechanoregulation of the Leukocyte Specific Integrin LFA-1 by the Actin CytoskeletonK01HL143111 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MOORE, TRAVIS I · 2018 to 2022
$856k
Alterations in somatodendritic bioenergetics in Drosophila models of tauopathyR01AG072176 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KARTIK VENKATACHALAM · 2025 to 2026
$766k
Metal responsive transcription factors in neurodegenerationR21AG087381 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI VENKATACHALAM, KARTIK · 2025 to 2025
$429k
Neuropathology in tauopathies stem from depolarization-induced alterations in the planar distribution of phosphoinositidesR01AG069076 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI VENKATACHALAM, KARTIK · 2025 to 2025
$383k
NHLBI NIH HHS K01 HL143111NIA NIH HHS R01 AG069076NIA NIH HHS R01 AG072176NIA NIH HHS R21 AG087381NIA NIH HHS RF1 AG069076NIA NIH HHS RF1 AG072176
6 · The paper itself

Abstract

Rates of lactate production and consumption reflect the metabolic state of many cell types, including neurons. Here, we investigated the effects of nutrient deprivation on lactate dynamics in

Indexed as

cell biologymolecular biologymolecular neuroscience

Identifiers

PMID41169509
PMCPMC12570357

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.