Evidence map›Paper›PMID 41169503›Full record

ArticleiScience2025

Cerebellar white matter development is regulated by fractalkine-dependent microglia phagocytosis of oligodendrocyte progenitor cells.

McKenzie K Chappell, John Shelestak, Muhammad Irfan, Eric Shelestak, Ashley D Nemes-Baran, Gabrielle M Mey, Lakshmi Venkat, Amulya Surabhi, Tara M DeSilva

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

McKenzie K ChappellDepartment of Neurosciences, Cleveland Clinic and Case Western Reserve University, Cleveland OH 44195, USA.
John ShelestakDepartment of Neurosciences, Cleveland Clinic and Case Western Reserve University, Cleveland OH 44195, USA.
Muhammad IrfanDepartment of Neurosciences, Cleveland Clinic and Case Western Reserve University, Cleveland OH 44195, USA.
Eric ShelestakDepartment of Neurosciences, Cleveland Clinic and Case Western Reserve University, Cleveland OH 44195, USA.
Ashley D Nemes-BaranDepartment of Neurosciences, Cleveland Clinic and Case Western Reserve University, Cleveland OH 44195, USA.
Gabrielle M MeyDepartment of Neurosciences, Cleveland Clinic and Case Western Reserve University, Cleveland OH 44195, USA.
Lakshmi VenkatDepartment of Neurosciences, Cleveland Clinic and Case Western Reserve University, Cleveland OH 44195, USA.
Amulya SurabhiDepartment of Neurosciences, Cleveland Clinic and Case Western Reserve University, Cleveland OH 44195, USA.
Tara M DeSilvaDepartment of Neurosciences, Cleveland Clinic and Case Western Reserve University, Cleveland OH 44195, USA.

Funding

Mechanisms of retinal degeneration in neuroinflammatory demyelinating diseasesR01EY032342 · NEI · CLEVELAND CLINIC LERNER COM-CWRU · PI DESILVA, TARA MARIA · 2021 to 2024
$1.6M
NEI NIH HHS R01 EY032342
6 · The paper itself

Abstract

Neurodevelopmental disorders often involve both motor and cognitive impairments, linked to the maturation of cerebral and cerebellar regions. This study reveals that during early postnatal development, ameboid microglia infiltrate the cerebellar white matter via the fourth ventricular zone, in parallel with similar activity in the cerebral white matter. These microglia phagocytose oligodendrocyte progenitor cells (OPCs) within a restricted time window before transitioning to a ramified state. The disruption of fractalkine receptor signaling-known to mediate synaptic pruning-reduces microglial OPC engulfment, leading to an increase in oligodendrocytes and altered myelin development. Variants in the fractalkine receptor gene have been linked to neurodevelopmental disorders such as autism and schizophrenia, both of which involve myelin abnormalities. These findings highlight a coordinated role of ameboid microglia in shaping white matter development in both the cerebrum and cerebellum, suggesting that disruptions in this process may contribute to altered brain circuitry and function in neurodevelopmental disorders.

Indexed as

Biological sciencesCellular neuroscienceDevelopmental neuroscienceNatural sciencesNeuroscienceSystems neuroscience

Identifiers

PMID41169503
PMCPMC12570368

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.