ArticleFrontiers in psychiatry2025
Social cognition and interactive training for first-episode, drug-naïve MDD patients.
Article in Frontiers in psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
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Authors and funding
6 authors.
Funding
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Abstract
Objective: This study aimed to explore the impacts of social cognition and interaction training (SCIT) on serum brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF) levels, and psychosocial function in first-episode, drug-naïve (FEDN) major depressive disorder (MDD) patients. Methods: In this 8-week randomized controlled trial (RCT), 45 MDD patients were assigned to SCIT group and 39 to cognitive behavioral therapy (CBT) group. The 17-item Hamilton Rating Scale (HDRS-17) and the Functioning Assessment Short Test (FAST) were performed to measure depressive symptoms and functional impairment severity, respectively. We also collected blood samples for serum BDNF/GDNF level detection. Results: Compared to CBT, SCIT demonstrated significantly greater improvements in total FAST scores ( Conclusion: Improvements in social function through SCIT can be effectively generalized to MDD patients. Moreover, improved GDNF levels were associated with improvements in specific aspects of social functioning post-SCIT.
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