Evidence map›Paper›PMID 41169453›Full record

ArticleChemical & biomedical imaging2025

Imaging Copper Levels during Life in the Brain and beyond Using a Fluorescent Copper Sensor with Multimodal Capacity.

Liam D Adair, Benjamin G Trist, Marcus E Graziotto, Tom J Hawtrey, Benjamin D Rowlands, Sarah A Rosolen, Veronica Cottam, Michael Kuligowski, Jessica L Chitty, Ellie T Y Mok and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical & biomedical imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Bioimaging of Metals.Chemical & biomedical imaging · 2026
    Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Liam D AdairSchool of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia.ORCID https://orcid.org/0000-0002-9527-4869
Benjamin G TristBrain and Mind Centre, The University of Sydney, Sydney, NSW 2006, Australia.ORCID https://orcid.org/0000-0002-0712-399X
Marcus E GraziottoSchool of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia.
Tom J HawtreySchool of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia.
Benjamin D RowlandsBrain and Mind Centre, The University of Sydney, Sydney, NSW 2006, Australia.
Sarah A RosolenBrain and Mind Centre, The University of Sydney, Sydney, NSW 2006, Australia.
Veronica CottamBrain and Mind Centre, The University of Sydney, Sydney, NSW 2006, Australia.
Michael KuligowskiSydney Microscopy and Microanalysis, The University of Sydney, Sydney, NSW 2006, Australia.
Jessica L ChittyCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, NSW 2010, Australia.ORCID https://orcid.org/0000-0003-1776-1618
Ellie T Y MokCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, NSW 2010, Australia.ORCID https://orcid.org/0009-0003-7750-3335
Thomas R CoxCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, NSW 2010, Australia.ORCID https://orcid.org/0000-0001-9294-1745
Michael P GotsbacherSchool of Medical Sciences, The University of Sydney, Sydney, NSW 2006, Australia.ORCID https://orcid.org/0000-0002-7153-1250
Kay L DoubleBrain and Mind Centre, The University of Sydney, Sydney, NSW 2006, Australia.
Elizabeth J NewSchool of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia.ORCID https://orcid.org/0000-0002-2310-254X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Copper is an essential trace element for normal development and function throughout the body, including the central nervous system (CNS). Alterations to cellular copper levels result in severe neurological consequences and are linked to a range of CNS disorders, positioning treatments that restore copper balance as promising therapies for these disorders. However, despite the clear relationship between copper balance and CNS health, there are limited tools to measure copper levels

Indexed as

braincopperintravital microscopyin vivo imagingneurologicalsensor

Identifiers

PMID41169453
PMCPMC12569956

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.