Evidence map›Paper›PMID 41169429›Full record

ArticleFrontiers in medicine2025

IL-5, IL-31 and systemic immune-inflammation index as biomarkers predicting severity and progression in bullous pemphigoid.

Yanyu Zhang, Xia Liu, Lili Hou, Yan Zhao, Jiaxuan Hao, Na Zhang, Jing Tian, Xiaoqing Li, Zhiyu Liu, Hongwei Zhou and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

13 authors.

Yanyu Zhang *Department of Laboratory Diagnosis, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Xia Liu *Department of Laboratory Diagnosis, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Lili HouDepartment of Laboratory Diagnosis, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Yan ZhaoDepartment of Laboratory Diagnosis, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Jiaxuan HaoDepartment of Laboratory Diagnosis, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Na ZhangDepartment of Laboratory Diagnosis, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Jing TianDepartment of Dermatology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Xiaoqing LiDepartment of Laboratory Diagnosis, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Zhiyu LiuDepartment of Laboratory Diagnosis, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Hongwei ZhouDepartment of Laboratory Diagnosis, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Chunyang XuDepartment of Clinical Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Yuan RenDepartment of Laboratory Diagnosis, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Haizhou ZhouDepartment of Laboratory Diagnosis, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Inflammatory mechanisms assume a pivotal role in bullous pemphigoid (BP). IL-31, IL-5, and the systemic immunoinflammatory index (SII) are emerging markers of inflammatory activity, but their associations with BP severity remain unclear. This investigation sought to investigate the correlation of the three aforementioned indicators with BP disease severity to determine their potential application in predicting BP severity. Methods: This study enrolled 83 BP patients and 50 healthy controls (HC). Patients were stratified into mild-moderate (MM, Results: Interleukin-31 and IL-5 levels were significantly raised in BP versus HC (median [Q1-Q3]: IL-5: 2.86 [1.22-7.10] vs. 0.79 [0.65-1.00] pg/mL; IL-31: 103.61 [77.42-146.77] vs. 86.02 [51.49-122.53] pg/mL), with further increases in Sev. versus MM groups (IL-5: 3.84 [1.57-10.63] vs. 1.35 [0.83-2.93] pg/mL; IL-31: 125.99 [91.58-173.85] vs. 65.14 [51.27-85.47] pg/mL). Post-treatment IL-31 decreased significantly in 5 patients (145.95 ± 44.25 vs. 108.62 ± 33.45 pg/mL). IL-5, IL-31, and SII positively correlated with BSA ( Conclusion: Interleukin-5, IL-31, and SII are promising biomarkers for assessing and predicting BP severity.

Indexed as

biomarkerbullous pemphigoiddisease severityinterleukin-31interleukin-5ROC curvesystemic immunoinflammatory index

Identifiers

PMID41169429
PMCPMC12568495

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