ArticleFrontiers in medicine2025
Histologically confirmed high-grade cervical intraepithelial neoplasia successfully treated with topical Paiteling: a two-case report.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: High-grade cervical intraepithelial neoplasia (HSIL) threatens fertility-aged women worldwide. Surgical excision remains standard but may compromise future pregnancy. Paiteling, a multi-herbal topical preparation, has shown Case presentation: Two reproductive-aged women with biopsy-proven HSIL refused loop electrosurgical excision. Biopsy slides were re-reviewed independently with p16 and Ki-67 immunostaining. Case 1 was CIN II and Case 2 was CIN III. Both patients received topical Paiteling (0.5 mL/lesion, three times weekly) plus 1% vaginal douche for 10 weeks. Intervention & outcome: Lesions regressed completely within the treatment course. HPV-DNA testing confirmed HPV clearance by week 12. Follow-up colposcopy, cytology and directed biopsy remained negative at 12 months (Case 1) and 16 months (Case 2). Only mild transient vaginal burning occurred. Conclusion: Topical Paiteling achieved histological and virological remission in two pathologically confirmed HSIL cases that declined excisional surgery. The findings suggest a fertility-preserving option worth systematic evaluation in prospective trials.
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