Evidence map›Paper›PMID 41169391›Full record

ArticleFrontiers in immunology2025

Mast cells are essential in the development of exposure-associated exercise-induced bronchoconstriction in a mouse model.

Nora F Marain, Fien Byttebier, Marieke Colemont, Ellen Dilissen, Jonathan Cremer, Dominique Ma Bullens, Lieven J Dupont, Jeroen A Vanoirbeek

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nora F MarainDepartment of Chronic Diseases and Metabolism, Laboratory of Respiratory Diseases and Thoracic Surgery, Katholieke Universiteit (KU) Leuven, Leuven, Belgium.
Fien ByttebierDepartment of Chronic Diseases and Metabolism, Laboratory of Respiratory Diseases and Thoracic Surgery, Katholieke Universiteit (KU) Leuven, Leuven, Belgium.
Marieke ColemontDepartment of Chronic Diseases and Metabolism, Laboratory of Respiratory Diseases and Thoracic Surgery, Katholieke Universiteit (KU) Leuven, Leuven, Belgium.
Ellen DilissenDepartment of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Group, Katholieke Universiteit (KU) Leuven, Leuven, Belgium.
Jonathan CremerDepartment of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Group, Katholieke Universiteit (KU) Leuven, Leuven, Belgium.
Dominique Ma BullensDepartment of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Group, Katholieke Universiteit (KU) Leuven, Leuven, Belgium.
Lieven J DupontDepartment of Chronic Diseases and Metabolism, Laboratory of Respiratory Diseases and Thoracic Surgery, Katholieke Universiteit (KU) Leuven, Leuven, Belgium.
Jeroen A VanoirbeekDepartment of Public Health and Primary Care, Environment and Health, Katholieke Universiteit (KU) Leuven, Leuven, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Cold air and air pollution are known triggers to induce symptoms in exercise-induced bronchoconstriction (EIB). Mast cells are hypothesized to be a key player in the pathogenesis of EIB. This study aims to investigate the role of mast cells using mast cell deficient (Cpa3 Methods: Male Cpa3 Results: Inhibition of mast cells by Doxantrazole or mice lacking functional mast cells (Cpa3 Conclusion: Mast cells are crucial in the development of bronchial hyperreactivity and macrophage activation. Additionally, they have a complex interplay with neutrophilic inflammation. These findings highlight the potential of mast cell modulation as therapeutic strategy in exposure-associated EIB.

Indexed as

Asthma, Exercise-InducedBronchoconstrictionMast CellsPhysical Conditioning, AnimalAnimalsCarboxypeptidases ACytokinesDisease Models, AnimalMaleMiceMice, Inbred BALB CCarboxypeptidases ACytokinescold airdiesel exhaust particlesdoxantrazoleexercise-induced bronchoconstrictionmast cells

Identifiers

PMID41169391
PMCPMC12568420

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.