ArticleFrontiers in immunology2025
Comparative immunophenotyping of peripheral blood lymphocyte subsets in pulmonary tuberculosis and nontuberculous mycobacterial pulmonary disease: a retrospective study.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To compare peripheral blood lymphocyte profiles between pulmonary tuberculosis (PTB) and nontuberculous mycobacterial pulmonary disease (NTMPD) patients and explore whether these immunophenotypic differences may assist future diagnostic algorithms. Methods: This retrospective study analyzed clinical data of 78 PTB patients, 73 NTMPD patients, and 80 healthy controls from the Shanghai Public Health Clinical Center between February 2024 and February 2025. Peripheral blood lymphocyte subsets were measured using flow cytometry. Logistic regression and receiver operating characteristic (ROC) curve analyses were performed to identify and assess diagnostic markers. Results: No significant differences in age or body mass index (BMI) were found among the three groups (P > 0.05), but gender distribution differed significantly (P < 0.05). PTB patients had a higher proportion of diabetes mellitus (P < 0.05), while NTMPD patients had a higher prevalence of structural lung disease (P < 0.05). PTB patients also showed higher platelet counts and CD3 Conclusion: Significant differences in peripheral blood lymphocyte subsets exist between PTB and NTMPD patients. The CD4
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