ReviewFrontiers in immunology2025
Advances in the combination of CAR-T therapy with small-molecule reagents for hematologic malignancies.
Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Chimeric antigen receptor T-cell (CAR-T) therapy has become a cornerstone of the treatment for hematologic malignancies. However, as a monotherapy, it still faces major challenges such as therapy resistance, disease relapse, and minimal residual disease (MRD) persistence post-remission. Small molecule compounds, such as Bruton's tyrosine kinase (BTK) inhibitors, hypomethylating agents, and immunomodulatory drugs, can augment the antitumor efficacy of CAR-T cells through multiple mechanisms, enhancing their persistence and the proliferative capacity. Combination therapy enables a synergistic attack on malignant cells to effectively eliminate MRD, overcome resistance, and improve overall therapeutic outcomes. To date, the combining of CAR-T therapy with small molecule agents has shown promising clinical potential in the treatment of hematologic malignancies, including acute lymphoblastic leukemia (ALL), diffuse large B-cell lymphoma (DLBCL), chronic lymphocytic leukemia (CLL) and multiple myeloma (MM). This review provides a comprehensive overview of the efficacy, safety and synergistic mechanisms of CAR-T therapy combined with Small-molecule reagents, and proposes optimization strategies to enhance clinical efficacy and minimize the adverse effects which may pave the way for future therapeutic development.
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