ArticleFrontiers in immunology2025
The evolutionary history of IGKC in mammals reveals ancient duplications and remarkable divergence in lagomorphs.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Proteomic Analysis of Retinas from Two Different Type-1 Diabetic Models.Biomolecules · 2026Article
- An update on the characterization of immunoglobulin loci inFrontiers in immunology · 2026Article
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Authors and funding
4 authors.
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Abstract
Background: The Immunoglobulin Kappa Constant ( Results: Using genomic sequences from NCBI and Ensembl, we expanded this to 124 Conclusions: Our study represents a significant contribution to the knowledge of the IGKC gene, substantially expanding on information available in IMGT. It highlights complex evolutionary trajectories, especially in lagomorphs. The presence of N-glycosylated sites suggests potential effects on antigen binding, stability, or half-life. The coexistence of purifying and episodic positive selection points to a balance between structural conservation and lineage-specific functional diversification.
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