ArticleFrontiers in immunology2025
Impacts of tacrolimus and glucocorticoids on peripheral blood T and B lymphocyte subsets in myasthenia gravis.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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4 authors.
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Abstract
Background: This study aimed to investigate the impact of tacrolimus on peripheral T and B lymphocyte subsets in myasthenia gravis (MG) patients compared to glucocorticoid treatment. Methods: This study retrospectively included MG patients at the First Affiliated Hospital of Fujian Medical University between January 2021 and December 2024. Patients were grouped based on immunotherapy received: tacrolimus (TAC) or glucocorticoids (GC). Peripheral blood samples were assessed for T lymphocyte subsets (CD3 Results: A total of 46 MG patients were included, with 23 patients in each treatment group. Baseline characteristics, including sex, age at onset, antibody profile, and thymic pathology, were comparable between the two groups (all P > 0.05), except for a significantly higher proportion of generalized MG in the TAC group (P = 0.017). Following treatment, the TAC group demonstrated a significantly lower absolute count of CD3 Conclusion: Compared with patients receiving glucocorticoid therapy, those treated with tacrolimus exhibited significantly lower levels of peripheral CD3
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