Evidence map›Paper›PMID 41169307›Full record

ArticleJTCVS open2025

Surgical versus transcatheter aortic valve replacement in patients age <65 years.

Eishan Ashwat, Sarah Yousef, James A Brown, Derek Serna-Gallegos, Nidhi Iyanna, Dustin Kliner, Catalin Toma, Amber Makani, David West, Yisi Wang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JTCVS open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Eishan AshwatDivision of Cardiac Surgery, Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, Pa.
Sarah YousefDivision of Cardiac Surgery, Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, Pa.
James A BrownDivision of Cardiac Surgery, Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, Pa.
Derek Serna-GallegosDivision of Cardiac Surgery, Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, Pa.
Nidhi IyannaDivision of Cardiac Surgery, Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, Pa.
Dustin KlinerHeart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pa.
Catalin TomaHeart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pa.
Amber MakaniHeart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pa.
David WestDivision of Cardiac Surgery, Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, Pa.
Yisi WangDivision of Cardiac Surgery, Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, Pa.
Jianhui ZhuDivision of Cardiac Surgery, Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, Pa.
Floyd ThomaDivision of Cardiac Surgery, Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, Pa.
Irsa HasanDivision of Cardiac Surgery, Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, Pa.
Takuya OgamiDivision of Cardiac Surgery, Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, Pa.
Ibrahim SultanDivision of Cardiac Surgery, Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, Pa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: American College of Cardiology/American Heart Association guidelines include a class I indication for surgical aortic valve replacement (SAVR) over transcatheter aortic valve replacement (TAVR) in patients age <65 years. This analysis assessed outcomes of SAVR versus TAVR in patients <65 years. Methods: This was a retrospective, single-institution study of consecutive SAVRs and TAVRs performed between 2013 and 2023. Patients age <65 years were included, and those who underwent concomitant operations or prior AVR were excluded. To balance the AVR cohorts, propensity score matching (PSM) was performed using a 1:1 match ratio. Short-term clinical and echocardiographic outcomes were compared. Kaplan-Meier survival estimation and Fine-Gray analysis of heart failure readmission were performed to evaluate mid-term outcomes after AVR. Results: A total of 761 patients age <65 years underwent AVR, including 655 with SAVR and 106 with isolated TAVR. PSM yielded a cohort of 97 SAVR patients and 97 TAVR patients age <65. After matching, the 2 groups were acceptably balanced across all baseline variables. No significant differences were observed in most immediate postoperative complications. Kaplan-Meier survival estimates were significantly lower for those who underwent TAVR, with 5-year survival rates of 46.3% for TAVR versus 79.7% for SAVR ( Conclusions: TAVR was significantly associated with decreased mid-term survival and increased heart failure readmissions compared to SAVR in patients age <65 years.

Indexed as

Fine-Gray modelKaplan-Meier survivalpropensity-score matchingsurgical aortic valve replacementtranscatheter aortic valve replacementunder 65

Identifiers

PMID41169307
PMCPMC12570539

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.