Evidence map›Paper›PMID 41169270›Full record

ArticleBrain communications2025

Amyloid and tau may moderate practice effects in semantic and episodic memory in a cognitively unimpaired at-risk sample.

Kristin Basche, Madeline Hale, Erin Jonaitis, Tobey J Betthauser, Bradley T Christian, Bruce P Hermann, Sterling C Johnson, Kimberly Mueller, Rebecca Langhough

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kristin BascheDepartment of Medicine, Division of Geriatrics and Gerontology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA.ORCID https://orcid.org/0000-0001-5767-8507
Madeline HaleDepartment of Communication Sciences and Disorders, University of Wisconsin-Madison, Madison, WI 53706, USA.
Erin JonaitisDepartment of Medicine, Division of Geriatrics and Gerontology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA.
Tobey J BetthauserDepartment of Medicine, Division of Geriatrics and Gerontology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA.ORCID https://orcid.org/0000-0001-8856-1352
Bradley T ChristianWisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA.
Bruce P HermannWisconsin Alzheimer's Institute, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA.ORCID https://orcid.org/0000-0003-0133-4427
Sterling C JohnsonDepartment of Medicine, Division of Geriatrics and Gerontology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA.
Kimberly MuellerDepartment of Communication Sciences and Disorders, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID https://orcid.org/0000-0001-8691-9517
Rebecca LanghoughDepartment of Medicine, Division of Geriatrics and Gerontology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA.

Funding

Novel Story Recall Measures as Indicators of Cognitive Decline Associated with Alzheimer's Disease and Related Disorders Biomarkers: A Collaborative Study of Existing DataR01AG070940 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Kimberly D Mueller · 2021 to 2026
$2.8M
NIA NIH HHS R01 AG070940
6 · The paper itself

Abstract

Previous studies in pre-clinical Alzheimer's disease have found associations between amyloid and practice effects. Additionally, studies within our research group have found associations between practice effects and cognitive tests, including language-based measures, as well as associations between language-based measures and Alzheimer's disease biomarkers. The purpose of this study is to bridge the gaps between these areas to further understand how practice effects may or may not explain additional variance between biomarker groups and to expand on current literature by incorporating tau status into these models. Our study had three main aims: (1) determine which of our proposed operationalizations of practice effects performed best, (2) explore the impact of amyloid on practice effects and (3) explore the impact of combined amyloid and tau status on practice effects for language-based measures: the proper names composite from the Logical Memory story recall task, as well as the total score, animal fluency, and letter fluency tasks. Participants from the Wisconsin Registry for Alzheimer's Prevention study with amyloid positron emission tomography (PET) scans and item-level Logical Memory data were included in these analyses (

Indexed as

Alzheimer’s diseaseLogical memoryPET biomarkerspractice effects

Identifiers

PMID41169270
PMCPMC12569600

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.