ArticleZoological research2025
Prenatal exposure to polystyrene nanoparticles induces neuroimmune dysregulation in the adult mouse brain.
Article in Zoological research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Weathered plastic particles negatively affect mouse primary neurons and glial cells.Archives of toxicology · 2026Article
- Microplastic Neurotoxicity in the Prefrontal Cortex: A Review of Mechanisms and Neuropsychiatric Associations.Toxics · 2026Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microplastics have been detected in the brain, raising concerns regarding their neurological health impacts. However, the specific cellular targets and functional consequences of their accumulation remain understudied. This study explored the primary brain cell types that internalize polystyrene nanoparticles (PSNs) and investigated their immunological responses. Results showed that PSNs preferentially localized to primary microglia and astrocytes. Functional assays revealed divergent effects on lipopolysaccharide (LPS)-stimulated immune responses in the two cell types: PSNs potentiated LPS-induced activation of microglia, whereas they suppressed activation in astrocytes. Apoptotic responses were likewise cell-type specific, with PSN reducing apoptosis in microglia independently of LPS, but enhancing it in astrocytes.
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