Evidence map›Paper›PMID 41169229›Full record

ReviewJournal of immunology (Baltimore, Md. : 1950)2025

Contributions of large and agricultural animal models to immunology.

Gerlinde R Van de Walle, Rebecca M Harman

Abstract readReview
In one paragraph

Review in Journal of immunology (Baltimore, Md. : 1950), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Gerlinde R Van de WalleBaker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY, United States.
Rebecca M HarmanBaker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY, United States.ORCID 0000-0002-8715-2562

Funding

Department of AgricultureElanco Animal HealthFoundation for Food and Agriculture Research CA20-SS-0000000004National Institute of Food and Agriculture 2022-67015-36351NCI NIH HHSNIH HHS 5R21CA285521-02NY Farm Viability Institute
6 · The paper itself

Abstract

While studies with laboratory rodent models have defined molecular and cellular components of the human immune system, experiments in these small mammals can't capture all aspects of human immunity. This review focuses on immunologic research in large and agricultural species, highlighting how understanding immunity in a range of large animals can expand awareness of immunological processes critical for maintenance of human health. Large animal studies are reviewed and their unique contributions to knowledge of infectious disease spread, antibody production and vaccine development, organ transplantation, and immunotherapies are demonstrated. The review concludes with a brief discussion of limits of large models and their importance not only to the health of humans, but to agricultural animals themselves and human food systems.

Indexed as

Allergy and ImmunologyDisease Models, AnimalModels, AnimalAgricultureAnimalsHumansImmunotherapyOrgan TransplantationVaccine Developmentagricultural animalsimmunologyone health

Identifiers

PMID41169229
PMCPMC12576136

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.