Evidence map›Paper›PMID 41169143›Full record

ReviewMini reviews in medicinal chemistry2026

A Comprehensive Analysis of the Therapeutic Potential of N-substituted Phenothiazine Derivatives in Medicinal Chemistry.

Deepanjali Shukla, Iqbal Azad, Mohd Arsh Khan, Sabahat Yasmeen Sheikh, Jamal Akhtar Ansari, Naseem Ahmad, Abdul Rahman Khan, Firoj Hassan

Abstract readReview
PubMed Publisher
In one paragraph

Review in Mini reviews in medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Deepanjali ShuklaDepartment of Chemistry, Integral University, Lucknow, 226026, India.
Iqbal AzadDepartment of Chemistry, Integral University, Lucknow, 226026, India.
Mohd Arsh KhanDepartment of Chemistry, Integral University, Lucknow, 226026, India.
Sabahat Yasmeen SheikhDepartment of Chemistry, Integral University, Lucknow, 226026, India.
Jamal Akhtar AnsariDepartment of Chemistry, Integral University, Lucknow, 226026, India.
Naseem AhmadDepartment of Chemistry, Integral University, Lucknow, 226026, India.
Abdul Rahman KhanDepartment of Chemistry, Integral University, Lucknow, 226026, India.
Firoj HassanDepartment of Chemistry, Integral University, Lucknow, 226026, India.ORCID 0000-0002-3675-9997

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phenothiazine and its N-substituted derivatives are pivotal in heterocyclic chemistry, and serves as potential building blocks in chemical and pharmaceutical sciences. Over the past decade, extensive research has focused on the medicinal potentials of these compounds, exploring their anticancer, analgesic, anti-tumor, anti-inflammatory, and antibacterial properties. Due to their distinctive chemical compositions, phenothiazine and its N-substituted derivatives have facilitated the development of novel substitutions. This paper reviews recent advancements in the synthesis of phenothiazine and its N-substituted derivatives, with an emphasis on their potential biological roles. Numerous investigations have identified various types of phenothiazine and its N-substituted derivatives that exhibit compelling biological characteristics. It discusses the impact of different functional groups on phenothiazine at the N-substitution, specifically Cl, CF₃, OH, N(C₂H₅)₂, and (CH₂)₅CH₃. Furthermore, the relationship between the biological activities and the structural characteristics of the compounds is examined, identifying the chemical groups and structural alterations that enhance bioactivity, reduce toxicity, and improve handling.

Indexed as

Antineoplastic AgentsPhenothiazinesAnalgesicsAnimalsAnti-Bacterial AgentsAnti-Inflammatory AgentsAnti-Inflammatory Agents, Non-SteroidalChemistry, PharmaceuticalHumansStructure-Activity RelationshipAnalgesicsAnti-Bacterial AgentsAnti-Inflammatory AgentsAnti-Inflammatory Agents, Non-SteroidalAntineoplastic AgentsphenothiazinePhenothiazinesbiological activitiesN-substitutionParkinson’s diseasePhenothiazinestructure-activity relationshipssynthesis

Identifiers

PMID41169143

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.